Oral submucous fibrosis is a chronic, precancerous condition, found to affect the South and South East Asian population especially those in the Indian subcontinent. The aspect of etiopathogenesis is still obscure, thereby accounting for extensive research in this field. Various etiological factors ranging from chilli consumption to arecanut and other environmental factors have been studied over the years. Due to the widespread use of the commercially available tobacco and arecanut products the incidence of the oral submucous fibrosis is very high in the central India . Studies have been done...