Histological, electrophysiological and behavioral studies suggest a regulatory role of GABA on the DAergic neurons. Behavioral studies in animals have demonstrated that drugs which influence the activity of central GABAergic systems modulate the intensity of behaviors dependent on the functional status of nigrostriatal and mesolimbic DAergic systems. Sodium valproate, enhances theGABAergic neurotransmission by acting through different mechanisms. Our study demonstrates that at higher doses valproate also enhances the central 5HTergic neurotransmission by releasing 5HT. Histological studies...
Histological, electrophysiological and behavioral studies suggest a regulatory role of GABA on the DAergic neurons. Behavioral studies in animals have...