This dissertation aims to develop, evaluate and use new radiogenic isotopic proxies for paleoceanographic and paleoclimatic reconstructions at sub-millennial resolution. The Fe-Mn oxyhydroxide fraction in marine pelagic sediments is an ideal archive for this purpose because seawater-derived trace metals such as neodymium (Nd), hafnium (Hf) and lead (Pb) can be chemically extracted from this fraction. This archive was already successfully used in earlier studies for the reconstruction of the seawater Nd isotope evolution in the South Atlantic, but no such record at sub-millennial resolution...