The present study was an attempt to develop microspheres for diltiazem HCl using three different polymers. Diltiazem HCl, being a hydrophilic drug was entrapped in the microspheres by w/o solvent evaporation method. To optimize the weight of polymer, totally five batches were prepared for each of the polymer and various evaluation parameters were studied. The ratio 1:2 (i.e. formulation ERS4) shows highest production yield, drug content and percentage entrapment among the all formulations. FTIR and XRD analysis was also carried out for pure drug and drug containing ethylcellulose, eudragit RS...

Form screening of thiazole group of compounds against various tumor cell line like HL60 and MCF-7, from results of MTT and XTT assay, It was found out that thiazole derivative potentially inhibits the proliferation of MCF-7 cells (human breast cancer) but not others cells like HL60 (human leukemia) and VERO (African monkey's Kidney cell) presumably because of interaction of compounds with specific breast cancer cells. Initial screening was carried out by using MTT assay. Results obtained from MTT assay and XTT assay clearly indicates that out of 13 compounds only 6 compounds (2, 5, 8, 9, 10,...