In-silico drug designing has become an important trend for some good reasons- first it cuts down drug designing lag time to a great extent and second it saves a significant sum of money invested for the process. Docking macromolecules to small ligands constitutes the central theme of this process and this in many ways is analogous to the conventional target based drug designing concept. However, unlike cell based therapy it is only limited to specific targets which are in most case protein molecules. Here, in this manuscript two studies of docking have been elucidated. Two small molecules,...

With the advent of potein sequence data the world has experienced a remarkable leap in scientist's interest to study proteins in a time dependent and stress dependent manner. With sequence and structural information rolling up newer mysteries regarding cellular milieu, whole protein study has become important in numerous applications such as exploring new biomarkers, diagnising diseases in vitro, identifying interaction partners, establishing cellular signaling pathways etc. Already significant advancements has been achieved in cancer research and toxicological study. In order to make up to...