Growth factors are a class of natural biologic mediators which regulate key cellular events in tissue repair i.e. cell proliferation, chemotaxis (directed migration), differentiation and matrix synthesis via binding to specific cell surface receptors. The expression of various growth and differentiation factors following bone and soft tissue injury like what happens in a periodontal disease may regulate the repair and regeneration process. The capacity of these mitogenic growth factors to initiate a programmed cellular cascade that results in the induction of bone in a functionally conserved...

One of the important goals of periodontal therapy is the restoration of the lost periodontium and conversion of the periodontitis affected root surface into a substrate, which is biologically hospitable for epithelial and connective tissue cell adherence and attachment. An objective of periodontal treatment is the predictable regeneration of the periodontium in areas previously affected by periodontal disease. Periodontitis affected root surfaces show many changes and the root is commonly referred to as 'pathologically exposed'. The traditional treatment of pathologically altered root...