Biostatistical analysis was carried out with Statistical Package for Social Sciences (SPSS) software to understand the significance of different signs and symptoms observed in Spondyloarthritis disease with specific geographic location to Gujarat, India. A Bioinformatics study was also carried out with investigational Dihyrofolate reductase (DHFR) inhibitors reported in Toxoplasma gondii and Lactobacillus casei using 2D- Quantitative Structure Activity Relationship (QSAR). Best scoring inhibitors from 2D-QSAR study provides new insight for designing optimized drugs to combat the disease.

Breast Cancer Resistance Protein (BCRP) is a membrane-associated protein and a member of the the super family of ATP-binding cassette (ABC) transporters known to confer multidrug resistance (MDR) to a number of important anticancer agent and play an important function in governing drug absorption. This book deals about the development of homology model of BCRP and its correspondence with experimentally known topology. This study also helped to understand the protein dynamics of BCRP through coarse-grained normal mode analysis. Structural analysis of substrate specificity bestowed by specific...