Periodontal disease is characterized by loss of tooth attachment apparatus, typically including periodontal ligament and supporting alveolar bone. Its etiology is primarily infective, resulting from a complex biofilm of commensals and periodontopathic bacteria and their products, triggering an inflammatory response. Defects in PMN have also been demonstrated to be associated with rapidly progressive, prepubertal, localized and generalized juvenile periodontitis. The pathologic sequlae of altered PMN function in the oral cavity and the mechanism that play a role in the functional abnormalities...