Tuberculosis (TB) is the major cause of death worldwide. The enormity of the problem has been further worsened by the emergence of multi-drug resistant (MDR) strains and the dual infection with HIV. A newly identified TB threat which leaves patients virtually untreatable using currently available anti-TB drugs is XDR-TB. Fluoroquinoloes are increasingly being used in the treatment of mycobacterial infections especially, tuberculosis and leprosy. Ciprofloxacin is an antibiotic that is used to treat bacterial infections. Ciprofloxacin stops the multiplication of bacteria by inhibiting the...