Epilepsy is a disorder of the central nervous system characterized by paroxysmal, excessive, hyper-synchronous discharges of large numbers of neurons. To identify novel and potent anticonvulsant ligands, initially 2D-QSAR,3D-QSAR and pharmacophore models were generated using a series some prop-2-eneamido and 1-acetyl-pyrazolin derivatives of aminobenzothiazole as anticonvulsants. To discover new hits, developed pharmacophore model was subjected to screen molecules from specs database. Screened hits which were showing good predicting activities according to both 2D and 3DQSAR models were...