For more than 30 years, pit and fissure sealants have been recommended for caries prevention, along with good oral hygiene, optimal fluoridation, and healthy dietary habits. To be effective in the prevention of pit and fissure caries, a sealant must truly seal, i.e. it must completely keep out fermentable food substrates. The pits and fissures are approximately eight times as vulnerable for dental caries as the smooth surfaces. In practice, the benefit of sealing should be considered locally and specified guidelines for clinicians should be used. As part of the evidence-based approach to...