Purpose of the study is to develope stable Methotrexate (MTX) loaded Microemulsion based formulation for topical treatment of Psoriasis with improvement in cutaneous deposition and to enhance the local effect. Several treatments of psoriasis are available, each specifically related to certain factors but none of these have curative effects. For practical purposes, patients with less than 15 % body surface involvement can be treated effectively with topical agents. In last few decades there is increasing in understandings of skin & its barrier properties which allowed development of more...

Aceclofenac is an effective analgesic and anti-inflammatory drug prescribed widely in recent years for various types of pain and inflammation. Aceclofenac is partially insoluble in water and aqueous fluid and as such it exhibits poor variable oral bioavailability. Aceclofenac needs enhancement of solubility and dissolution rate to improve its oral bioavailability and therapeutic efficacy. Among the various approaches to enhance the solubility and dissolution rate of poorly soluble drugs complexation with cyclodextrin is an effective and industrially accepted technique. In the present...