This work is intended to serve as an introduction to the principles and techniques used in the field of 2D-Quantitative Structure Activity Relationship (QSAR). Itlays foundation of certain information and skills that can be repeatedly employed in the field of computer added discovery of new lead and in the discovery of new drugs. A good introductory book of QSAR should contain (i) explain the fundamental concept in not too stilted language together with generous use of appropriate equation and diagrams; (ii) provide sufficient examples with detailed solution; (iii) present ideas in the...

Diabetes mellitus is a complex, progressive lifestyle disease resulting in chronic hyperglycemia, which in turn adversely affects function of the kidneys, eyes, nervous and vascular systems. The classical antidiabetic agent sulphonylurea, biguanides have lots of side effects like mild to moderate hypoglycemia, lactic acidosis, increased cardiovascular mortality, transient nausea, anorexia or diarrhoea, abdominal discomfort, and metallic taste etc. Various 5-substituted thiazolidine-2,4-dione derivatives are also known to potentially act on PPARs. There has been a surge of interest in the...