The isolation of the unsymmetrical Schiff bases posed some challenges. Majority of unsymmetrical Schiff bases reported in the literature were synthesized via a stepwise approach. There are only a few procedures which proceed via a one-pot condensation approach because the introduction of different carbonyl groups might lead to the formation of a mixture of products. But by fine-tuning some of the reaction conditions we were able to isolate the desired unsymmetrical Schiff bases at room temperature. The new synthetic procedure for the preparation of the unsymmetrical Schiff bases was developed...