Modification of the structure of a known drug is one way to develop new drugs. For this purpose, we have optimized the pyrimidobenzimidazole derivatives using molecular modeling studies. QSAR analysis has been carried out on a series of pyrimidobenzimidazole derivatives using the physicochemical parameter and molecular descriptors. The database was subjected to QSAR studies using Chemsketch software version 10.0 and all the parameter & descriptors were calculated using TSAR 3D version 3.3 for windows. The regression analysis has shown that SFI (Shape flexibility index), R (Randic index), B...

Inflammatory diseases and cancer are serious health problems for mankind. Many antiinflammatory and a few anticancer drugs are available in the market. Most of the drugs used clinically have serious side effects and hence there is a development of safer antiinflammatory and more active anticancer drugs. In continuation of our work in this direction, we have synthesized a number of pyridine, pyrazine, pyrimidine, pyrimidobenzimidazole, hemin & hematoporphyrin derivatives and evaluated them for their antiinflammatory, analgesics and/or anticancer activities. A few of them are very potent...