Since ages body fluids routinely used for diagnostic purposes are blood, urine, tears and cerebral spinal fluid but these fluids require more invasive collection procedures, potentially causing discomfort and stress to the patient during procurement. Since 2002, the National Institute of Dental and Craniofacial Research (NIDCR) created opportunities to overpower these limitations by investigating oral fluids as a diagnostic tool for assessment of health and disease status. In the past 50 years salivary research has picked up the pace with the dawn of new techniques that illuminated the...