This book focuses on some related problems in medical diagnosis for the identification of the perfect biomarkers which in turn help to classify the subjects into one of the two groups or populations. A brief introduction about the concept of clinical trials and a basic introduction to the concept of ROC curves have been discussed. Literature review has been presented on the three different approaches such as non-parametric, parametric and semi-parametric for estimating and testing various procedures of ROC curve. Specific spreadsheet templates and solutions have been developed to perform ROC...