Floating Drug Delivery Systems have emerged as an efficient means of enhancing the bioavailability and controlled delivery of Diltiazem hydrochloride. Drug absorption in the gastrointestinal tract is a highly variable processes and prolonging the gastric retention of dosage form via floating drug delivery system extends the time for drug absorption and ultimately increase bioavailability of drug. Diltiazem hydrochloride is a benzothiazepine-derivative calcium-channel blocker was chosen as a model drug due to its low oral bioavailability (30-40 %), short half-life (3 to 4 hrs), High frequency...
Floating Drug Delivery Systems have emerged as an efficient means of enhancing the bioavailability and controlled delivery of Diltiazem hydrochloride....
