IDO has a role in immunosuppressive and tolerogenic mechanism in many solid tumor cells. Upregulation of IDO in acute myeloid leukemia has been recently reported. This book presents our research work which assessed both the IDO RNA expression & its enzymatic activity in the blast cells of AML patients. It also assessed the effect of pharmacological IDO inhibitor (1MT) on culture leukemia blast cells in relation to the effect of most traditionally used chemotherapeutic agent: adriamycin. The study included 25 AML patients & 25 healthy volunteers. All underwent assessment of IDO enzymatic...