Triptolide is the main component of extracts of the medicinal plant Tripterygium wilfordii Hook F. and used for systemic treatment of autoimmune disorders. The mechanism of action of triptolide involves the inhibition of differentiation of murine CD4+ T cells into Th17 cells, decreased transcription of IL-17 mRNA. In a CD4+ T-cell line of mice AhR expression is restricted to the Th17 cell subset and its binding to agonists results in the production of the Th17 cytokines. Our study showed that in naive T cells differentiated Th17-cells the addition of triptolide significantly decreased...

This volume is a collection of original articles or reprints of journal papers and book chapters written or inspired by Berge Englert, as well as essays recounting Professor Englert's impact on all the contributors' scientific careers and lives in general. The scientific articles span a wide range of topics in quantum physics - from quantum optics, foundations of quantum physics, to quantum information - reflecting his influential impact. The personal essays offer a rare insight into the man behind the science - the essence of who he is. Each article in the book is preceded by a commentary...

This book constitutes the thoroughly revised selected papers of the 6th workshop on Big Data Benchmarks, Performance Optimization, and Emerging Hardware, BPOE 2015, held in Kohala Coast, HI, USA, in August/September 2015 as satellite event of VLDB 2015, the 41st International Conference on Very Large Data Bases.

The 8 papers presented were carefully reviewed and selected from 10 submissions. The workshop focuses on architecture and system support for big data systems, aiming at bringing researchers and practitioners from data management, architecture, and systems research communities...