Biochemical processes in living organisms predominantly take place in aqueous environments where the structure and function of biomolecules are greatly modulated through interactions with water. One and two-dimensional infrared spectroscopy provides rich structural information since each chemical structure exhibits a unique set of vibrational frequencies. However, following the fastest changes of the DNA hydration shell geometries, occurring in the time domain below 1ps, can only be achieved using ultrafast vibrational spectroscopy. The author first provides a short introduction to the field...