Mitral regurgitation (MR) affects millions of patients world-wide. It is a progressive disease which worsens when left untreated. MR leads to compensatory remodeling of the left ventricle resulting in reduced functional capacity, poor quality of life, repeat hospitalizations, and eventually death from heart failure. Open, arrested heart surgery has until now been the therapeutic treatment of choice. However, many high-risk patients cannot tolerate traditional heart surgery and continue to suffer from severe MR.In this exciting new title, international key opinion leaders discuss in-depth the...