A brief introduction of M.tuberculosis has been summarized. Pharmacological importance and literature survey of pyrazolo derivatives has been summarized. All the synthesized compounds were characterized by UV, IR, Mass and 1H-NMRspectroscopy. All the newly synthesized compounds have been screened for antibacterial activity. Streptomycin was used as standard reference drug. Compound 57b has been found to have better antibacterial activity against gram+ve bacteria S.aureus and B.subtilis as compared to other synthesized compounds. Compounds 57b, 58a, 58b have been found to have better activity...

Obesity Can Also Lead To Life-threatening Conditions Including Type 2 Diabetes, Insulin Resistance, High Blood Pressure, Heart Disease, Sleep Problems, Cancer And Other Disorders. The Prevention And Treatment Of Excess Weight Is Critical For The Health Of Both Individuals And Our Society. The Disease Therefore Incurs An Increasingly Heavy Burden Not Only On Overweight And Obese Citizens Themselves But Also On Health Care Systems, The Efficiency Of The Workforce And Society At Large. Obesity Is Frequent, Serious, Complex And Chronic.We Will Be Grateful To All The Readers Who Finally Judge The...

This research work has been done by Dr. Meghal V. Modi under the guidance of Prof. Dr. Dhrubo Jyoti Sen during his M.Pharm. in quality assurance specialization on the dissertation Method development for purity of synthesized asymmetric mixture having chiral carbon during 2006-2008 at Shri Sarvajanik Pharmacy College, Mehsana. This work has been presented at international conference: Meghal Vinodchandra Modi and Dhrubo Jyoti Sen; Chiral synthesis of Mannich bases and separation of racemic mixtures: International Conference of Chemistry in the New World of Bioengineering and Synthetic Biology:...

0Design, synthesis and biological evaluation of sulphonyl urea and guanidine derivatives as hypoglycemic agents Design and synthesis of sulphonyl urea and guanidine derivatives as hypoglycemic agents has been performed which is based on the indirect molecular modeling approach by checking the superimposibility of the designed molecule and reported compound N-(6-substituted-1,3-benzothiazol-2-yl)-benzene-sulfonamides. Synthesized compounds were characterized by TLC, UV spectra, IR spectra, Mass spectra & 1H NMR. All the synthesized compounds were subjected to OGTT to gain preliminary...

The CNS stimulation study has been performed on the two semisynthetic adducts of caffeine with Schiffs base of pyrazolone and pyrazolone-pyrimidine nucleus. All the reference drugs and test compounds showed positive effect on CNS stimulation. The conclusion has been drawn from the fact that CNS stimulation effect for pentylene tetrazole is higher than caffeine, Molecule-I (pyrazolone ring) is less active than Molecule-II as the Molecule-II (pyrazolo-pyrimidine ring) is fused ring heterocyclic compound and the synergistic action with caffeine with Molecule-I having less activity than the...