Cancer is a term that encompasses a complex group of more than 100 different types of diseases associated with uncontrolled cell division. Epigenetic events are alterations in gene expression without changes in DNA sequence and characteristic of heritability via cell division. Certainly, it is anticipated that aberrant changes bring about epigenetic control through chromatin modifying enzymes. This has an important bearing on future therapies for human diseases including cancer.
Cancer is a term that encompasses a complex group of more than 100 different types of diseases associated with uncontrolled cell division. Epigenetic ...
Breast Cancer Resistance Protein (BCRP) is a membrane-associated protein and a member of the the super family of ATP-binding cassette (ABC) transporters known to confer multidrug resistance (MDR) to a number of important anticancer agent and play an important function in governing drug absorption. This book deals about the development of homology model of BCRP and its correspondence with experimentally known topology. This study also helped to understand the protein dynamics of BCRP through coarse-grained normal mode analysis. Structural analysis of substrate specificity bestowed by specific...
Breast Cancer Resistance Protein (BCRP) is a membrane-associated protein and a member of the the super family of ATP-binding cassette (ABC) transporte...
Microarray technology is a novel technique to identify the Evaluation of differentially expressed gene.This is very useful for the stastical analysis of DNA chip using different stastical software's.This work is attempted to work on microarray analysis on Alzheimer's disease and identify the differentially expressed gene and their reannotation using R and Biocondcutor.R language is freely available and its latest release is Biocondcutor Software. Here, R language and Biocondcutor software is used for the stastical analysis of hippocampus sample of Alzheimer's disease.The data get normalized...
Microarray technology is a novel technique to identify the Evaluation of differentially expressed gene.This is very useful for the stastical analysis ...
Microarray is a novel technology to identify gene expression of thousands of genes simultaneously. This work is attempted to perform microarray data analyses to determine differential gene expression using the open-source R programming environment in conjunction with the open-source Bioconductor software.We describe procedures for analysis of data using box plots and recommended procedures from Affymetrix for quality control are discussed. The Robust Multichip Averaging (RMA) and MAS5 procedure was used for background correction, normalization and summarization of the AffyBatch probe-level...
Microarray is a novel technology to identify gene expression of thousands of genes simultaneously. This work is attempted to perform microarray data a...
