Solid dispersion technology has proved to be a powerful technique in the field of drug delivery of poorly water soluble drugs by enhancing the dissolution rate and bioavailability of that drug. Here we used four drugs namely Spironolactone, Etoricoxib, Ibuprofen and Carvedilol. Solid dispersions were prepared by solvent co-precipitation method, where acetone was used as solvent and pet-ether was used as anti solvent. Different water soluble polymer (HPMC 6cps, Kollicoat IR, Kollidon VA 64 and HPC), and as an excipient poloxamer were used to prepare solid dispersion. Paddle type dissolution...

Solid dispersion techniques have been widely used as an effective method for enhancing the dissolution rate and bioavailability of poorly water soluble drugs. Current study was conducted to reveal the possibility of preparing repaglinide solid dispersions with improved aqueous solubility and dissolution rate, which will solve the difficulties in the development of pharmaceutical dosage forms of poorly water soluble drugs due to their limited water solubility, slow dissolution rate and low bioavailability. Repaglinide solid dispersion was prepared considering different variable factors:...