Ceftriaxone is a third generation cephalosporin antibiotic with broad spectrum of activity against Gram-positive and Gram-negative bacteria. It interferes with the peptidoglycan synthesis of bacterial cell wall, thus weakening the cell wall which cannot resist osmotic pressure and ruptures. It is the most widely prescribed antibiotic and there is a possibility of its interactions with other drugs. In present work, drug interactions of ceftriaxone were studied with non-steroidal anti-inflammatory drugs, statins, H2-receptor antagonists, Ca-channel blockers, ACE-inhibitors, quinolone and...