A stability indicating RP-HPLC method was developed and validated for the determination of Gemifloxacin in tablet formulation. The drug was subjected to forced degradation study in terms of acidic, thermal, oxidative, photo and basic stresses. Degradation products produced as a result of stress testing were successfully separated through C18 column (250 x 4.6 mm, 5 m) using ammonium acetate buffer (pH 2.7; 0.05 M) and acetonitrile (70:30, v/v) as a mobile phase at a flow rate of 0.7 mL/min. The diode array detection was performed at 272 nm. The method was linear over the concentration range...
A stability indicating RP-HPLC method was developed and validated for the determination of Gemifloxacin in tablet formulation. The drug was subjected ...