C-reactive protein is a highly conserved plasma protein and a preferred marker for diabetes. High sensitivity CRP is associated with insulin resistance, metabolic syndrome and type2 diabetes. High level of CRP is associated with indices of metabolic syndrome that include obesity, hypertriglyceridemia, low HDL, hypertension and high blood pressure. Inflammation such as insulin resistance, insulin secretion abnormality, obesity and lipolysis act as inflammatory stimulus for the elevated level of CRP. Plasma CRP level is high in metabolic syndromes than non-metabolic syndrome subjects....

Diabetes mellitus is a chronic disease which is caused by hyperglycemia. Glycaemia is a major risk factor to cause renal disease. Considering Pakistan national diabetes survey, Pakistan ranks 7th highest worldwide in the prevalence of diabetes. The importance of blood glucose control for the subsequent prevention of diabetic complications is well established This study was conducted on the incidence of nephropathy and assessment of kidney functions among the newly diagnosed diabetic patients from Pakistani population. This study was aimed to assess the overall prevalence and frequency of...

Diabetes is among the major worldwide issue. The aim of the intended study was to assess the Vitamin D status in T2DM subjects in order to evaluate the relationship of associated potential risk factors. This cross sectional study was conducted on 90 Type 2 diabetic patients. Patients with age 38 to 67 years included 29 males and 61 females. Three groups were made based on glycemic level (mmol/L) and other demographic parameters including age (years), BMI (kg/m2), B.P (mm/Hg), personal history, socioeconomic status etc were recorded. The biochemical parameters including FPG (mmol/L), RPG...

Diabetes mellitus refers to a range of conditions that are all characterized by elevation of the blood glucose level due to insulin deficiency or impaired insulin action. This study was conducted to evaluate the levels of IGF-1 in T2DM patients. Total 88 subjects were included. Mean age value of all the subjects was 46.93 0.923 years, mean value for BMI was 30.56 0.541 kg/m2, mean value for WHR was 0.975 0.005, mean age value of fasting plasma glucose was 140.94 3.577 mmol/L, mean value of cholesterol was 219.26 3.299 mg/dl, mean value of triglyceride was 226.22 11.985 mg/dl, mean value of...

Diabetes mellitus is a multifactorial disorder. Cytokines secreted by the monocyte-macrophage system play a key role in the pathogenesis of type 2 diabetes. Pro-inflammatory cytokine TNF- is believed to have an important role in the progression of diabetes. The present study was conducted to assess the level of TNF- and to find its relationship with insulin sensitivity and other indicators of metabolic syndrome among newly diagnosed type II diabetic subjects. 100 diabetic subjects (age; 48.63 0.92, BMI; 28.51 0.52) were included in the study. Four groups were made on the basis of BMI as...