Immune tolerance ensures that the immune system responds to foreign molecules and not to self-molecules. When tolerance breaks down, severe, self-destructive diseases such as rheumatoid arthritis, lupus, and multiple sclerosis may develop. Understanding the mechanisms involved in establishing and maintaining immune tolerance is essential for effectively treating these autoimmune diseases. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology reviews how self- tolerant T- and B-cell populations are produced. The contributors discuss the...
Immune tolerance ensures that the immune system responds to foreign molecules and not to self-molecules. When tolerance breaks down, severe, self-dest...
