The rate and extent of dissolution of the active ingredient from any solid dosage form determines the rate and extent of absorption of the drug. Potential bioavailability problems are prevalent with extremely hydrophobic drugs due to erratic or incomplete absorption from gastro intestinal tract. Clinically, HMG Coenzyme reductase inhibitors are the most frequently prescribed drugs for cholesterol reduction. Simvastatin, potent inhibitor of 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase which catalyzes the conversion of 3-hydroxy-3-methyl-glutaryl-coenzyme A to mevalonate, which is an early...