AMD is the main cause of registered blindness in the Western World and despite recent advances, there is very limited treatment. Transplantation of RPE under the macula represents a potential treatment. We investigated methods to establish an intact functioning RPE monolayer on an artificial substrate that could eventually be implanted under the macula and substitute for damaged native Bruchs membrane. Biomaterials polydimethylsiloxane (PDMS) and expanded polytetrafluoroethylene (ePTFE) are already used widely clinically. Cells, however, do not attach to PDMS and ePTFE. The aim of...