Stopping to help a mugging victim transforms Dr. Sally Graff's life forever. The unknown man's iridescent blue eyes and other genetic defects create a growing medical mystery for both Sally and Detective Dan Lawson. Working together they discover a strange cultish group bent on destruction. But what are they trying to do and why? As Sally and Dan try to answer these questions, they are running out of time, and the more they learn brings them face to face with an unthinkable reality.

When Doctor Sally Lawson examines a patient arriving in Northwestern Hospital's emergency room, she immediately understands the implications of the strange combination of symptoms. Her hospital and the city are about to fight a battle not seen since the Chicago Fire. Sally and her husband, Detective Dan Lawson, along with the FBI and CIA, are committed to the search for those responsible. The emerging facts point to the involvement of the Iranian Government, and if proven, the attack is certainly an act of war.