The Wnt/Beta-catenin signaling pathway is a key regulator of cell fate specification, differentiation, and growth in multiple systems throughout the animal kingdom. In vertebrate posterior neural development, Wnt/Beta-catenin signaling controls this complex multistep process. It initially induces the posterior regions of the nervous system, including the mid-hindbrain border, hindbrain, spinal cord and neural crest, and then subsequently fine-tunes the pattern of each region and determines the different cell fates within them. In this review, we explore the function of the Wnt/Beta-catenin...