Phosphate homeostasis is of critical importance for a wide variety of functions and is a function of intestinal absorption and renal elimination. Renal tubular phosphate absorption is accomplished by the Na+, phosphate cotransporter NaPi IIa. The mammalian target of rapamycin mTOR is known to stimulate a variety of transport mechanisms. The present study thus explored the impact of Akt/PKB, SGK1, Nedd4-2 and mTOR on the regulation of NaPi-IIa. For this purpose the NaPi-IIa was expressed in Xenopus oocytes with or without PKB/Akt, SGK1, Nedd4-2 and mTOR and Na+, phosphate transport was...