piRNA pathway represses transposon transcripts, regulates telomere extension, and maintains genome integrity during the gamatogenesis. The transposons transcripts are catalytically cleaved through an elegant Ping-Pong cycle, and piRNA mediated heterochromatin formation and the transcriptional silencing of transposons are also known to occur. In the cuff mutants, elevated DNA damage, upregulated transposons, and the disintegrated nurse cell nuages are observed. Cuff-GFP shows germline specific nuclear foci that closely overlap with heterochromatin markers and interact with HP1...