Described as the body's largest organ, the skin is strategically located at the interface with the external environment where it has evolved to detect, integrate and respond to a diverse range of stressors including UV radiation. Recent findings have established the skin as a peripheral neuroendocrine organ that is tightly networked to central stress axes. This capability contributes to the maintenance of skin's and body's homeostasis. Specifically, epidermal and dermal cells produce and respond to classical stress neurotransmitters, neuropeptides and hormones, and this production is modified...