The present publication focusses the attention on new avenues in regional information and knowledge management, while we will zoom in particularly on the potential promises and hurdles of digital technology. This digital challenge has already generated a wealth of implications in the area of smart or intelligent cities, but as yet far less has been achieved in the field of regional planning and regional science. There is clearly a need for a more systematic and wide-ranging assessment and presentation of emerging approaches and concepts in this field, for instance, in regard to principles...