This paper deals mainly with human cognition and usability aspects of e-commerce websites, specifically regarding tourism portals. In the last years tourism has risen to be one of the most advanced economic sectors for e-commerce and is represented in almost every regions and culture. The different tourism portals win more importance by each day and are visited by the most different users, each expecting it to fulfill his needs. For this reason we are using this branch as a main reference to analyze usability and cognition aspects.