The resistance of malaria parasites to widely used drugs prompted an upsurge in the development of new drugs with novel mechanism of action, and re- evaluation of the existing drugs to overcome the resistance problem. A number of new potential target pathways have already been identified and efforts to develop lead compounds for these putative targets hopefully will allow treatment of malaria infections in a uniform sustained way. Considerable research efforts were directed in the areas of chloroquine drug resistance reversal agents. Careful development of some bisquinolines, which...

The objective of this work is to study the response of this neutrophile in an acidic environment with respect to the activities of isocitrate, malate, succinate and G-6-PD on being coupled to the electron transport chain. E.coli have an optimum pH range of 6 to7 for growth and survival and are hence,called neutrophiles. When challenged by low pH, protons enter the cytoplasm; as a result mechanisms are required to alleviate the effects of lowered cytoplasmic pH. This study highlights new insights into activities of isocitrate, succinate, malate and G-6-PD, coupled to the electron...

Antimicrobial resistance is now threatening the management of infections such as pneumonia, tuberculosis, malaria and AIDS.So at present scenario there is a great need for developing new anti-infective agents.Heterocycles are an inescapable and integral feature of numerous diverse branches of chemistry.The presence of heterocycles in all kinds of organic compounds of interest in biology, pharmacology, optics, electronics, material sciences.Among the heterocyclic compounds, five member heterocyclic moieties fused with aromatic ring system with various heteroatom like N, S, and O have possess...

Oracle e-Business Suite Payroll R12 is written for new and intermediate users, key-users and administrators. It focuses on your role in an Oracle eBS-environment and explains the Concepts, describes the main Screens, gives Step-by-Step instructions with navigation paths and has a Glossary and FAQ-list. All chapters have Questions and Answers. The book has six chapters, 81 pages and has lots of screenshots and illustrations. With this book you learn the main concepts like: Assignment and Consolidation Sets, Defining a new Payroll, running a Payroll run, Balance Feeds and Balance Dimension,...

Fully revised, this second edition presents trainees with the latest guidance on preparation for OSCE examinations. Comprised of fourteen chapters, the book covers all the key learning points and provides an understanding of the basic concepts behind the OSCE and advice on appropriate response.