Benzodiazepines represent a large and important class of psychotherapeutic agents acting on the central nervous system. Due to their tranquilizer, anti-depressive and sedative properties they have become the drugs of choice for the treatment of anxiety, sleep disorders, status epilepsy, insomnia, frequent nocturnal, early morning awakenings or other convulsive disorders. This book compromises brief discussion on structure, properties and the effects of benzodiazepines, comprehensive review on sample preparation and determination of these drugs in biological samples by HPLC methods to be...

Benzodiazepines are used as hypnotics, tranquilizers, anticonvulsants or muscle relaxants whereas antidepressants are used for the treatment of psychiatric disorders such as depression. Antidepressants also possess tranquilizing properties. Many of the benzodiazepines are also used in combination with antidepressants in the management of depression. For the medical treatment of depression and neurosis, the concomitant administration of tricyclic antidepressants and benzodiazepines is widely used. A unique HPLC-UV method has been developed for the simultaneous quantitation of...