Les neurones noradrA(c)nergiques (NA) du locus coeruleus et sA(c)rotonergiques (5-HT) du raphA(c) dorsal sont fortement impliquA(c)s dans la rA(c)gulation des A(c)tats d''A(c)veil et de sommeil. Ils ont une activitA(c) tonique au cours de l''A(c)veil, diminuent leur dA(c)charge au cours du sommeil lent et sont silencieux au cours du sommeil paradoxal (sommeil du rAave). NA(c)cessaire A l''endormissement et A la survenue du rAave, l''inactivation des neurones NA et 5-HT fait ici l''objet de diffA(c)rentes hypothA]ses testA(c)es sur un nouveau modA]le expA(c)rimental de rat non anesthA(c)siA(c)...

Stereotaxic neurosurgery in rodents is used by a variety of people working at research laboratories (research staff, technicians, students at animal facilities...). The present handbook presents all the steps necessary to complete a stereotaxic neurosurgery protocol in accordance with current animal welfare guidelines. This book will guide surgeons step by step, from anesthesia to the post-surgery recovery procedures, including asepsis of the surgical tools and surgical zone, analgesia, correctly identifying the reference points on the skull and brain targets, etc. In keeping with the current...

From anesthesia to post-surgery recovery procedures, this book presents all the steps necessary to complete a stereotaxic neurosurgery protocol on rodents in accordance with current animal welfare guidelines.