Strains of Salmonella Paratyphi A isolated from the patients admitted to the diarrhoea treatment center of ICDDR, B were characterized both at the phenotypic and genotypic levels. Antibiotic susceptibility test revealed that 61% of the strains (n = 19) were sensitive to all the antibiotics used for empirical treatment of paratyphoid fever and 32% strains (n = 10) were resistant only to nalidixic acid. Most of the strains that showed reduced susceptibility to ciprofloxacin, having elevated MIC value (0.5ug/ml). A point mutation in the gyrA gene was observed at codon 83 (TCC to TTC), which...

A total of 9 experiments were carried out at different doses (100, 200 and 400 mg/kg, p.o.) of Dhatri Lauha(DTR)which was studied in different animal model to find out the various degrees of significant action of the drug on mice (Swiss-Webster strain, 20-40 gm body weight). Highly significant (p=0.009) increase in ambulation behavior was observed in Hole board test and highly significant (p=0.005) increase in motor activity was observed in Hole cross test. Open field test showed significant (p=0.036) increase in Standing up behavior. Climbing out test produced a significant (p=0.039)...