Cryosurgery is a surgical technique that employs freezing to destroy undesirable tissue. From as early as 3500 BC, there is evidence for the use of cold in medicine for the treatment of infected wounds of the chest, fracture of the skull and various injuries. However, the history of "modern" cryosurgery is relatively short and is closely intertwined with the development in low temperature physics, engineering, and instrumentation during the last century. From the early 21st century, advanced helium-based cryosurgery has been applied worldwide. More than ten thousand patients with malignant...