The behavior of lymphocytes in the immune system depends on encounters with antigens. These bind to immunoreceptors on the surface of T-cells and B-cells, activating a variety of signal transduction pathways that control cell survival, proliferation, differentiation, and effector functions.
Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology includes contributions covering the structures of the T-cell and B-cell immunoreceptors, the numerous kinases and adaptors that associate with their intracellular tails, and the downstream...