As the concept of Green Chemistry becomes ever more important, the findings presented in this book may provide efficient and atom-economical approaches to the diversity-oriented synthesis of bioactive compounds containing a complex structure.
As the concept of Green Chemistry becomes ever more important, the findings presented in this book may provide efficient and atom-economical approa...
A copper-catalyzed direct synthesis of 2-(aminomethyl)indoles by catalytic domino reaction including multi-component coupling was developed, and is the first example of a three-component indole formation without producing salts as a byproduct. Based on this reaction, a copper-catalyzed synthesis of 3-(aminomethyl)isoquinoline was accomplished which represents an unprecedented isoquinoline synthesis through a four-component coupling reaction. Following these results, extensive application studies using one-pot palladium-, acid-, or base-promoted cyclization revealed that indole- or...
A copper-catalyzed direct synthesis of 2-(aminomethyl)indoles by catalytic domino reaction including multi-component coupling was developed, and is th...
