Progeria (also known as "Hutchinson-Gilford progeria syndrome" and "Hutchinson-Gilford syndrome") is an extremely rare, severe, genetic condition wherein symptoms resembling aspects of aging are manifested at an early age. The disease has a very low incidence and occurs in one per eight million live births.Those born with progeria typically live about thirteen years, although many have been known to live into their late teens and early twenties and rare individuals may even reach their forties. It is a genetic condition that occurs as a new mutation and is not usually inherited, although...

Sustained release of macromolecular drugs from polymeric matrices has received increasing attention in recent years. Vaccines that are required to be given in multiple divided doses are not efficacious if only one dose is given without boosting. In order to be effective, most vaccines require two or three booster doses after primary immunization. Therefore, the conversion of multiple dose vaccines into single dose vaccines may represent an important advance. Among the various tentative for improving the administration of proteins, the microencapsulation into biodegradable polymers represents...

Wound is defined simply as the disruption of the cellular and anatomic continuity of a tissue. Wound may be produced by physical, chemical, thermal, microbial or immunological insult to the tissue. Attention should be directed towards discovering an agent, which will accelerate wound healing either when it is progressing normally, when it is suppressed by various agents like corticosteroids, anti neoplastics.or non- steroidal anti-inflammatory agents. Medical treatment of wound includes administration of drugs either locally (topical) or systemically (oral or parenteral) in an attempt to aid...

The aim of this study was to develop a depot formulation of mirtazapine by w/o emulsification method using chitosan as controlled release biodegradable polymer. Chitosan microspheres are used to provide controlled release of mirtazapine and to improve the bioavailability of degradable substances or enhance the uptake of hydrophilic substances across the epithelial layers. The effect of various parameters, such as stirring rate, drug to chitosan ratio, chitosan concentration and glutaraldehyde concentration on entrapment efficiency and release study was studied. Stirring speed affects the size...

The aim of the present study was to enhance the dissolution and bioavailability of aceclofenac by using a natural biodegradable polymer, chitosan.Recently, natural polymers such as polysaccharides and proteins have received much attention in the pharmaceutical field owing to their good biocompatibility and biodegradability. Among polysaccharides, chitosan has been considered to be one of the most promising biopolymer for drug delivery systems. The approach was to precipitate chitosan over drug crystals in the presence of a salting out agent sodium citrate, along with micronization of drug...

To analyze internal movement, I developed an anatomical classification system based on combinations of possible joints and muscle contractions resulting in movement of the hand, which maintains its same absolute location in the signing space. Using this coding system, I mapped the frequency of internal movement types across a languages set of internal movement signs. These results allowed me to speculate on the properties of the articulator that most readily allow sign languages to change or innovate. In addition, I looked at the prevalence of marked and unmarked hand configurations and...

In this present investigation anti oxidant activity of Achyranthes aspera was evaluate to certify that this methanol extract may be beneficial and may utilize for vivo assessment in different kind of biological activity such as anti asthmatic, antimicrobial, antiulcer activity because ulcer is formed due to stress, alcohol consumption.