Despite recent advances in adjuvant therapies of cancer, the regi- mens of postoperative adjuvant chemotherapy treatment which are presently available fail to cure the majority of cancer patients. Pre- operative (neoadjuvant) chemotherapy represents a new approach in drug scheduling, based on sound theoretical, pharmacokinetic, and experimental principles. The preoperative timing of chemotherapy before definitive sur- gery is not a minor change in the therapy of cancer. To be successful, large numbers of practitioners and their patients must participate. Substantial alterations of many...