Une decouverte scientifique . . . n'est ja mais l'reuvre d'un seul homme et chacun de ceux qui y ont concouru lui ont donne bien des veilles. Louis Pasteur Traditionally every volume of the Handbook of Experimental Pharmacology is expected to give a comprehensive account of the topic it is devoted to. This is a relatively easy task if the subject has a short history, but if the problems in question have been worked on for half a century or longer the feasibility of integral coverage becomes questionable. In such cases more attention is usually given to the literature of the last decades,...