Magnetic-Particle-Imaging (MPI) ist ein neues bildgebendes Verfahren, das es ermoglicht, die Verteilung superparamagnetischer Nanopartikel in hoher zeitlicher und ortlicher Auflosung zu bestimmen. Das Auflosungsvermogen des Systems hangt dabei direkt von dem fur die Ortskodierung genutzten Selektionsfeld ab. Kurzlich wurde ein MPI-Scanner vorgestellt, der dieses Selektionsfeld mit Permanentmagneten generiert. Ausgehend von dieser Anordnung werden in diesem Werk die Geometrie- und Magnetisierungsparameter der Permanentmagneten optimiert. Durch die erreichte Erhohung der Gradientenstarke um 39...

Magnetic Particle Imaging (MPI) is a novel medical imaging technology that is able to acquire the distribution of superparamagnetic iron oxide nanoparticles in real-time with high spatial and temporal resolution. Spatial encoding is realized by a magnetic field configuration generating a field-free point (FFP). Therefore, the FFP is moved through the field of view (FOV). However, at low particle concentrations the signal-to-noise ratio (SNR) decreases and therefore image quality worsens. An enhanced encoding scheme uses instead of the FFP the concept of a field-free line (FFL), whereby a gain...

Magnetic Particle Imaging is a functional imaging technique used to visualize the distribution of superparamagnetic iron oxide nanoparticles by using magnetic fields. These fields are generated by current carrying coils specifically arranged in different scanner topologies. Up to now, the established geometries of a coil have been either circular shaped or rectangular shaped. The aim of this work is to evaluate the application of approximated elliptical coils. Based on the clinical practice, it is conceivable to integrate a circular single-sided scanner, for example, into a patient table. In...