The enormous potential that hyperthermia has for benefiting patients with cancer is impressively indicated by biological studies, both in vitro and in vivo, and by comparative clinical studies whenever the heat has been appro priate to the size of the tumor. But hyperthermia, as with any other technologically based medical procedures, requires an extensive develop ment of sophisticated instrumentation and techniques to offer routine clinical benefit. We probably erred in starting clinical trials so soon. We had hoped that by showing the clinical benefits on some superficial tumors quickly,...